Pharmaceutical
In the early stages of drug discovery, a drug candidate needs to be characterized for critical "go" or "no go" decision making. The bottleneck in drug discovery process is the Absorption, Distribution, Metabolism, Excretion and Toxicology (ADMET) evaluation within a living organism. Therefore, technology increasing the analytical throughput for such analysis is essential in drug discovery. By using the LDTD for ADMET studies, you will perform one analysis every 4 seconds dramatically increasing throughput compared to current LC-MS/MS method of analysis. Moreover, many more applications can benefit from this analytical speed.
View how the LDTD can increase your drug discovery process
Scientific Publication
- Journal of Pharmaceutical and Biomedical Analysis 2011, 54, pp 1088-1095 Laser Diode Thermal Desorption-Positive Mode Atmospheric Pressure Chemical Ionization Tandem Mass Spectrometry For The Ultra-Fast Quantification of a Pharmaceutical Compound in Human Plasma, Olivier Heudi, Samuel Barteau, Pierre Picard, Patrice Tremblay, Franck Picard, and Olivier Kretz. DOI:10.1016/j.jpba.2010.11.025.
- Journal of Pharmaceutical and Biomedical Analysis 2011, 55, pp 544-551 Simultaneous quantitation of metformin and sitagliptin from mouse and human dried blood spots using laser diode thermal desorption tandem mass spectrometry, John G. Swales, Richard T. Gallagher, Mark Denn, Raimund M. Peter,. DOI:10.1016/j.jpba2011.02.030
- Journal of Pharmaceutical and Biomedical Analysis 2010, 53, pp 740-744 Determination of metformin in mouse, rat, dog and human plasma samples by laser diode thermal desorption/atmospheric pressure chemical ionization tandem mass spectrometry, John G. Swales, Richard Gallagher and Raimund M. Peter. DOI:10.1016/j.jpba.2010.04.033
- Analytical Chemistry 2007, 79(12), pp 4657-4665 High-throughput Cytochrome P450 Inhibition Assays Using Laser Diode Thermal Desorption-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry, Jin Wu, Christopher S. Hughes, Pierre Picard, Sylvain Letarte, Mireille Gaudreault, Jean-François Lévesque, Deborah A. Nicoll-Griffith, and Kevin P. Bateman DOI: 10.1021/ac070221o
- Note : The results published into the Analytical Chemistry (2007) paper were obtained with a beta-LDTD ion source. Therefore, the laser power reported should not be used with the current LDTD ion source models. Moreover, Phytronix has observed that for more accurate CYP 1A2 results, the probe whould be monitor in negative mode. Please refer to the application note 0714 (below) for updated operation conditions.
Application notes
- AN-1107 : 4.8 Seconds Sample-to-Sample Analysis in ADME Using LDTD-TripleTOF 5600
- AN-1106 : Extraction and Analysis of Drug on LDTD-384 Platform
- AN-1105 : LDTD-MS/MS Method Validation According to FDA Regulation.
- AN-1003 : CACO-2 Permeability Coefficient Determination in LDTD-MS/MS.
- AN-1002 : High Throughput Workflow Analysis : Dextrorphan in Human Plasma.
- AN-0706 : High Throughput Analysis of 960 Reserpine Samples in 1.9 hours.
- AN-0708 : LDTD-MS/MS in 1.8 seconds with RSD of 2.4 % : Paracetamol in Human Plasma Crash.
- AN-0709 : Midazolam and 1-Hydroxymidazolam in Human Plasma : LDTD-MS/MS Analysis in 8 Seconds.
- AN-0710 : LDTD-MS/MS Analysis in 9 Seconds : Quantification of Mifepristone in Mouse Plasma.
- AN-0714 : High Throughput LDTD-MS/MS IC50 Determination of CYP Inhibition in HLM.
Oral Presentations
Oral presentation produced by LDTD users
Oral presentation produced in collaboration with LDTD users
Posters
Posters produced by LDTD users
Posters produced in collaboration with LDTD users