Toxicology

New methods demonstrated, both during validation and in clinical lab production since 2009 are available for analysis of drugs of abuse.

LDTD-MS/MS analysis time is 12 seconds sample to sample compared to conventional GC/MS time of up to15 minutes per sample!

Drug testing in urine and plasma are achieved using the LDTD ionization source and are 50 times faster than any data published. Fast screening combined with accurate quantification results allows your lab to increase analytical capacity and dramatically reduce turn over time.

What's next? View how the LDTD performed drug testing:

Application notes

• AN-1110 Fast and Selective screening of 34 drugs of abuse in urine using LDTD-TripleTOF 5600
• AN-0711 LDTD High-Throughput Screening and Quantification of Doping Agents in Human.
• AN-1104  Confirmation of Methadone and EDDP in Urine by LDTD
• AN-1103 Confirmation of Propoxyphene and Norpropoxyphene in Urine by Laser Diode Thermal Desorption (LDTD)
• AN-1108 Fast K2/Spice Analysis using LDTD-Triple TOF 5600
• AN-0713 LDTD-MS/MS for CYP 1A2/ 2C9/ 2D6/ 3A4 inhibition assays

Note: AN-1104 and AN-1103 were demonstrated during validation and in clinical laboratory production since 2009. 

Posters

Posters produced by LDTD users

• ASMS 2011 Laser Diode Thermal Desorption (LDTD)-LC-MS-MS poster
• Spice-K2 Analysis on LDTD-MS/MS Evaluation
• ASMS 2010 Laser Diode Thermal Desorption (LDTD)-MS/MS Analysis of Chloroquine, Proguanil and Mefloquine in Human Urine

Posters presented in collaboration

• SOFT-TIAFT 2011 Confirmation of Propoxyphene and Norpropoxylene in Urine by Laser Diode Thermal Desorption (LDTD)
• SOFT-TIAFT 2011 Confirmation of Methadone and EDDP in Urine by Laser Diode Thermal Desorption (LDTD)
• ASMS 2009 High Throughput Workflow for Midazolam and 1-Hydroxymidazolam Analysis in Human Plasma.
• ASMS 2008 High-Throughput screening and Quantification of Doping Agents in Urine Using LDTD-APCI-MS/MS.